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My perspectives as an investor and consumer

A glimpse into the future VI

RobertTurner_LightBulbThis week’s look into the world of cutting edge research:

  1. Herbal extract inhibits the development of pancreatic cancer. An herb appears to inhibit development of pancreatic cancer as a result of its anti-inflammatory properties, according to researchers from the Kimmel Cancer Center at Jefferson who presented their work at the 100th meeting of the American Association of Cancer Research.  Thymoquinone, the major constituent of the oil extract from a Middle Eastern herbal seed called Nigella sativa, exhibited anti-inflammatory properties that reduced the release of inflammatory mediators in pancreatic cancer cells, according to Hwyda Arafat, M.D., Ph.D.  “Not only patients with chronic pancreatitis could benefit from this, but also several other groups with risk of development or recurrence of pancreatic cancer, such as high-risk family members and post-surgical patients. These potent effects show promise for the herb as a potential preventive and therapeutic strategy for pancreatic cancer,” Dr. Arafat said.
  2. Reversible generation of high capacity hydrogen storage material demonstrated. Researchers at the U.S. Department of Energy’s Savannah River National Laboratory have created a reversible route to generate aluminum hydride (alane), a high capacity hydrogen storage material. This achievement is not only expected to accelerate the development of a whole class of storage materials, but also has far reaching applications in areas spanning energy technology and synthetic chemistry.  For years, one of the major obstacles to the realization of the hydrogen economy has been hydrogen storage. Solid-state storage, using solid materials such as metals that absorb hydrogen and release it as needed, has many safety and practicality advantages over storing hydrogen as a liquid or gas.  Alane possesses the desired qualities but until now, had been considered impractical because of the high pressures required to combine hydrogen and aluminum to reform the hydride material.
  3. ‘Designer’ immune cells created with the help of microscopic ‘beads’ ignore transplanted organs. The future of organ transplantation could include microscopic beads that create “designer” immune cells to help patients tolerate their new organ, Medical College of Georgia researchers say. The degradable microparticles deliver the most powerful known form of HLA-G, a natural suppressor of the immune response, straight to dendritic cells, which typically show the immune system what to attack. The microparticles are given right after a transplant, just as dendritic cells are giving the immune system a heads up to get busy attacking the new organ. Unlike current anti-rejection drugs that generally suppress the immune system – leaving patients vulnerable to infections, cancer and more – HLA-G offers specific “tolerance.” Marked microparticles also have treatment potential in diseases where the immune system attacks normal tissue, such as arthritis, multiple sclerosis and inflammatory bowel disease.
  4. New approach to scrambling light may lead to sharper images, wider views. When photographers zoom in on an object to see it better, they lose the wide-angle perspective — they are forced to trade off “big picture” context for detail. But now an imaging method developed by Princeton researchers could lead to lenses that show all parts of the scene at once in the same high detail.  The new method could help build more powerful microscopes and other optical devices.  This method addresses the shortcomings of small apertures by taking advantage of the unusual properties of substances called nonlinear optical materials. In conventional lens materials such as glass or plastic, rays of light pass through without interacting with one another. In nonlinear materials, light rays mix with each other in complex ways.  The image from a nonlinear lens would therefore be rich in detail once the information is unscrambled, which is what the researchers have been able to accomplish.
  5. Physical reality of string theory demonstrated. String theory has come under fire in recent years. Promises have been made that have not been lived up to. Leiden theoretical physicists have now for the first time used string theory to describe a physical phenomenon. Their discovery has been reported in Science Express.  Electrons can form a special kind of state, a so-called quantum critical state, that plays a role in high-temperature super-conductivity.  Super-conductivity only seemed possible at very low temperatures close to absolute zero, but more and more examples are coming up where it also occurs at higher temperatures.  However, no one had managed to explain this phenomenon.  The quantum-critical state occurs in a material just before it becomes super-conductive at high temperature, where the electrons exhibit the same behavior at small quantum mechanical scale or at macroscopic human scale.  An aspect of string theory has been used by the Leiden physicists to shed light on this phenomenon.

Filed under: Health, Science, Technology, ,

A glimpse into the future V

Webster_Messenger1.  A new target may help maintain healthy blood pressure. In trying to understand the role of prostaglandins – a family of fatty compounds key to the cardiovascular system – in blood pressure maintenance, researchers at the University of Pennsylvania School of Medicine discovered that mice that lack the receptor for one type of prostaglandin – PG F2-alpha – have lower blood pressure and less atherosclerosis than their non-mutant brethren. The normal role for PG F2-alpha is to increase blood pressure and accelerate atherosclerosis, at least in rodents.  Targeting this pathway could represent a novel therapeutic approach to cardiovascular disease.  Results were published in the Proceedings of the National Academy of Sciences.  The delicate balance the body maintains to keep blood pressure stable involves not only the prostaglandin system, but another biological pathway, the renin-angiotensin-aldosterone system, or RAAS.  Mice lacking the PG F2-alpha receptor also showed reduction in levels of renin, angiotensin I, and aldosterone, a biological situation leading to lower blood pressure.

2.  A smartphone can now serve as an ultrasound imager. William D. Richard and David Zar, researchers at Washington University in St. Louis, are bringing the minimalist approach to medical care and computing by coupling USB-based ultrasound probe technology with a smartphone, enabling a compact, mobile computational platform and a medical imaging device that fits in the palm of a hand.  It is now possible to build smartphone-compatible USB ultrasound probes for imaging the kidney, liver, bladder, and eyes, endocavity probes for prostate and uterine screenings and biopsies, and vascular probes for imaging veins and arteries for starting IVs and central lines.  The vision of the new system is to train people in remote areas of the developing world on the basics of gathering data with the phones and sending it to a centralized unit many miles, or half a world, away where specialists can analyze the image and make a diagnosis.  A typical, portable ultrasound device may cost as much as $30,000. Some of these USB-based probes sell for less than $2,000 with the goal of a price tag as low as $500.

3.  Blood cells can be reprogrammed to act as embryonic stem cells. In a recent study, U.S. researchers have reprogrammed cells found in circulating blood into cells that are molecularly and functionally indistinguishable from embryonic stem cells which provide a readily accessible source of stem cells and an alternative to harvesting embryonic stem cells. Embryonic stem cells have long been coveted for their potential to treat a multitude of diseases as a result of their unique properties of self-renewal and pluripotency (the ability to develop into any type of cell in the body), but their use has been the subject of political controversy.  To generate induced pluripotent stem cells (dubbed iPS cells), scientists isolated CD34+ cells – a type of stem cell that produces only blood cells – from blood samples.  The CD34+ cells were infected with viruses carrying reprogramming factors that can reset the blood cells to an embryonic state. The colonies of cells exhibited physical characteristics similar to embryonic stem (ES) cells and expressed the same markers as ES cells.

4.  A super-fast 167-processor chip is ultra energy-efficient. A new, extremely energy-efficient chip, containing an array of 167 processors, that provides breakthrough speeds for a variety of computing tasks has been designed by a group at the University of California, Davis. The chip, dubbed AsAP, is ultra-small, fully reprogrammable and highly configurable, so it can be widely adapted to a number of applications. The chip is designed for digital signal processing. While not the principal kind of processor chip used in desktop computers, digital signal processing chips are found in a myriad of everyday and specialized devices such as cell phones, MP3 music players, video equipment, anti-lock brakes and ultrasound and MRI medical imaging machines.  Twelve chips working together could perform more than half-a-trillion operations per second (.52 Tera-ops/sec) while using less power than a 7-watt light bulb – up to 10 times the speed of currently available chips while decreasing power consumption up to 75 times.  Details of the chip design have been published in IEEE Journal of Solid State Circuits.

5.  The future of infrastructure could be in self-healing concrete. A concrete material developed at the University of Michigan can heal itself when it cracks. No human intervention is necessary, just water and carbon dioxide.  Self-healing is possible because the material is designed to bend and crack in narrow hairlines rather than break and split in wide gaps, as traditional concrete behaves.  Self-healed specimens recovered most, if not all, of their original strength after researchers subjected them to a 3 percent tensile strain.  It’s the equivalent of stretching a 100-foot piece an extra three feet – enough strain to severely deform metal or catastrophically fracture traditional concrete.  Traditional concrete will fracture and cannot carry a load at .01 percent tensile strain.  Today, builders reinforce concrete structures with steel bars to keep cracks as small as possible. But they’re not small enough to heal, so water and deicing salts can penetrate to the steel, causing corrosion that further weakens the structure.  The self-healing concrete needs no steel reinforcement to keep crack width tight, so it eliminates corrosion.

Filed under: Health, Science, Technology, ,

A glimpse into the future III

lyndi-0-lHere is this week’s look into the world of cutting edge research:

  1. A therapeutic target in Alzheimer’s disease identified. Work led by Professor Mark Pepys FRS over more than 20 years has identified a protein known as serum amyloid P component (SAP) as a possible therapeutic target in Alzheimer’s disease.  In collaboration with Roche he developed a new small molecule drug, CPHPC, which specifically targets SAP and removes it from the blood. In the exciting new work reported in the Proceedings of the National Academy of Sciences, the Pepys team has shown that the drug also removes SAP from the brains of patients with Alzheimer’s disease. In this first study of the drug in patients with Alzheimer’s disease, CPHPC was given to 5 individuals for 3 months.  There was the usual depletion of SAP from the blood, seen in all subjects receiving this treatment, but also remarkable disappearance of SAP from the brain. Laboratory tests revealed for the first time the way in which SAP accumulates in the brain in Alzheimer’s disease.
  2. Nanosensors could lead to development of highly sensitive security and medical devices. Scientists have designed tiny new sensor structures that could be used in novel security devices to detect poisons and explosives, or in highly sensitive medical sensors, according to research published in Nano Letters. The new ‘nanosensors’, made of gold or silver, are about 500 times smaller than the width of a human hair. One is shaped like a flat circular disk while the other looks like a doughnut with a hole in the middle. When brought together they interact with light very differently than they do on their own.  This difference in the interaction with light is affected by the composition of molecules in close proximity to the structures.  The device could be tailored to detect different chemicals by decorating the nanostructure surface with specific ‘molecular traps’ that bind the chosen target molecules. Once bound, the target molecules would change the colors that the device absorbs and scatters, alerting the sensor to their presence.
  3. Understanding and preventing the movement of tumor cells. Tumor cells that lack a certain protein can become extremely mobile and “adept” at penetrating healthy tissue to form metastases. Scientists at the Pharmacology Institute of the University of Heidelberg have identified this protein as the previously unknown cell signal factor SCAI (suppressor of cancer cell invasion).  When the factor’s functioning was disrupted, the cancer cells moved much more effectively. They adapted to the consistency of the respective tissue by changing their shapes constantly and attaching flexibly to surrounding tissues during movement with the help of special surface structures (receptors).   One of these receptors is known as b1-integrin. Suppression of SCAI causes b1-integrin to be overactive and the tumor cell to take on an aggressive form.  The discovery of SCAI, presented in the prestigious journal Nature Cell Biology, could be an interesting starting point for research into new mechanisms for fighting cancer.
  4. Advances in organic LED’s may provide cheap and efficient natural light. Roughly 20 percent of the electricity consumed worldwide is used to light homes, businesses, and other private and public spaces. Though this consumption represents a large drain on resources, it also presents a tremendous opportunity for savings. Improving the efficiency of commercially available light bulbs — even a little — could translate into dramatically lower energy usage if implemented widely. In the Journal of Applied Physics, a group of scientists at the Chinese Academy of Sciences is reporting an important step towards that goal with their development of a new type of light emitting diode (LED) made from inexpensive, plastic like organic materials. Designed with a simplified “tandem” structure, it can produce twice as much light as a normal LED — including the “natural” white light desired for home and office lighting.  Progress in this area promises further reduction in the price of organic LEDs.
  5. Doctors look to an inexpensive drug to relieve fibromyalgia pain. Fibromyalgia is a disorder classified by chronic widespread pain, debilitating fatigue, sleep disturbance and joint disorder. Advocates and doctors who treat the disorder, estimate it affects as much as 4 percent of the population.  In a small 14-week pilot study at Stanford, patients were given a low dose of a drug called naltrexone for the treatment of chronic pain.  The drug, which has been used clinically for more than 30 years to treat opioid addiction, was found to reduce symptoms of pain and fatigue an average of 30 percent over placebo, according to the results of the study published in the journal Pain Medicine.  “Patients’ reactions were really quite profound,” said senior author Sean Mackey, MD, PhD, associate professor at Stanford University Medical Center. Still, Mackey and his colleagues remain cautious about recommending the drug this early on in the research process.  The researchers are moving ahead with a second, longer-term trial of 30 patients who will be tested during a 16-week period.

Filed under: Health, Science, Technology, ,

A glimpse into the future II

ashbee_work02In this second issue of what I intend as a weekly tradition, I present five recent research findings from diverse areas:

  1. Stem cell therapy grows new blood vessels. Research led by David Hess at The University of Western Ontario has identified how to use selected stem cells from bone marrow to grow new blood vessels to treat diseases such as peripheral artery disease.  It’s one of the severe complications often faced by people who’ve had diabetes for a long time.  Reduced blood flow (ischemia) in their limbs can lead to resting pain, trouble with wound healing and in severe cases, amputation. The research is published in Blood.  These stem cells have a natural ability to hone in on the area of ischemia to induce blood vessel repair and improve blood flow.  The preclinical data from Hess’ research was used by a biopharmaceutical company, Aldagen (www.aldagen.com ) to receive FDA approval for a multi-center clinical trial now underway in Houston, Texas, involving 21 patients with end-stage peripheral artery disease.  “These principles could be applied not only to ischemic limbs, but to aid in the formation of new blood vessels in ischemic tissue anywhere in the body, for example after a stroke or heart attack.” says Hess.
  2. Algae could help in manufacture of solar panels that are simpler and more efficient. Engineers at Oregon State University have discovered a way to use an ancient life form to create one of the newest technologies for solar energy.  The secret: diatoms.  These tiny, single-celled algae have dye-containing rigid shells that can be used to generate electricity in a natural way at a nanoscale.  Researchers have created a new way to make “dye-sensitized” solar cells, in which photons bounce around inside the shells like they were in a pinball machine, striking these dyes and producing electricity.  This technology may be slightly more expensive than existing approaches to make dye-sensitized solar cells, but can potentially triple the electrical output.  These solar cells work well in lower light conditions and offer manufacturing simplicity and efficiency.  The process involves letting the diatoms settle on a transparent conductive glass surface.  The living organic material is removed, leaving behind the tiny skeletons of the diatoms to form a template.  Titanium dioxide is then precipitated creating a thin film semiconductor for the dye-sensitized solar cell device.  This process was presented in ACS Nano.
  3. If you think current microprocessor fabrication is impressive, think again. The ability to create tiny patterns is essential to the fabrication of computer chips and many other current and potential applications of nanotechnology. Yet, creating ever smaller features, through a widely-used process called photolithography, has required the use of ultraviolet light, which is difficult and expensive to work with.  John Fourkas, Professor of Chemistry and Biochemistry at the University of Maryland, and his research group have developed a new, table-top technique called RAPID (Resolution Augmentation through Photo-Induced Deactivation) lithography that makes it possible to create small features without the use of ultraviolet light. This research was published in Science magazine.  Nanofabrication has depended on short wavelength ultraviolet light to generate ever smaller features.  RAPID lithography allows the creation of patterns twenty times smaller than the wavelength of light employed and structures that are 2500 times smaller than the width of a human hair.  RAPID is expected to find applications in areas such as electronics, optics, and biomedical devices.
  4. What if you could repair the damaged cells following a heart attack? A protein that the heart produces during its early development reactivates the embryonic coronary developmental program and initiates migration of heart cells and blood vessel growth after a heart attack, researchers at UT Southwestern Medical Center have found. The molecule, Thymosin beta-4 (TB4), is expressed by embryos during the heart’s development and encourages migration of heart cells. The new findings in mice suggest that introducing TB4 systemically after a heart attack encourages new growth and repair of heart cells. The study appears in the Journal of Molecular and Cellular Cardiology.  “This molecule has the potential to reprogram cells in the body to get them to do what you want them to do,” said Dr. J. Michael DiMaio, associate professor of cardiothoracic surgery at UT Southwestern and senior author of the study. Obviously, the clinical implications of this are enormous because of the potential to reverse damage inflicted on heart cells after a heart attack.”
  5. The dream of a Hydrogen Economy moves one step closer to reality. The design of efficient systems for splitting water into hydrogen and oxygen underpins the long term potential of hydrogen as a clean, sustainable fuel. But man-made systems that exist today are very inefficient and often require additional use of sacrificial chemical agents.  Prof. David Milstein and colleagues of the Weizmann Institute’s Organic Chemistry Department demonstrated a new mode of bond generation between oxygen atoms and even defined the mechanism by which it takes place.  Their results were recently presented in Science magazine.  The new approach is divided into a sequence of reactions, which leads to the liberation of hydrogen and oxygen in consecutive thermal- and light-driven steps, mediated by a “smart” complex consisting of a metal core – ruthenium – and an outer organic part.  They were able to demonstrate the production of hydrogen gas, oxygen gas, and reversion of the metal complex to its original state.  For their next study, they plan to combine these stages to create an efficient catalytic system, bringing those in the field of alternative energy an important step closer to realizing this goal.

Filed under: Health, Science, Technology, ,

A glimpse into the future

dettmer3_1This is the debut of a weekly post, “A glimpse into the future” where I present five research findings as published in various scientific journals.  These projects represent the cutting edge of scientific research.

Advancements in science and technology form the foundation for future economic growth.  Many of these projects are a decade or two from producing applications or products for consumer use.  The ones that make it could significantly improve our quality of life.  As an investor, some of these may serve as candidates for sizeable returns.

  1. Fluorescent cancer cells could guide brain surgeons. Gliomas are malignant brain tumors that arise from glial (supporting) cells of the brain. Gliomas are often resistant to chemotherapy. These tumors grow fine extensions that infiltrate normal brain tissue and, in addition, individual tumor cells can form satellites in surrounding tissue. Therefore, it is almost impossible to remove the tumor tissue completely by surgery. Yet, radical surgical removal of the tumor would substantially improve the prognosis of patients.  The scientists took advantage of the fact that tumors cover their increased energy needs, among other things, by taking up large amounts of the blood protein albumin. The researchers attached a fluorescent substance (5-aminofluorescein) to albumin, which is distributed throughout the body via the bloodstream and eventually accumulates in the brain tumor. Laser light causes the substance to glow and makes the fine extensions of the tumor visible.  The scientists tested the albumin method in thirteen patients with malignant gliomas. In nine cases it was possible to remove the fluorescent tumor tissue completely thanks to the intensive yellow-green light signal.  The researchers calculated that the probability of the glowing tissue being tumor cells is 97 percent.  Tolerability and effectiveness of the staining method will be validated next year in a larger study involving several hospitals.
  2. Worrying about hard drive failures may be a thing of the past. Physicists at the University of Leeds and scientists at IBM Research’s Zurich lab have made new advances in researching a new kind of memory, called  ‘racetrack’ memory, which could become the standard method of storing information on home computers. Racetrack memory, a concept invented by Stuart Parkin at IBM Research’s Almaden Lab, has no moving parts – instead it is the information which moves. Using a kind of physics called spin transfer, scientists use electrons (in the form of electrical current) to switch the magnetism of the domains, pushing them to a different location along a nanowire.  Racetrack memory looks to combine the benefits of flash – no moving parts, with that of a hard drive – low cost.  It is significantly faster than hard disks as there are no ‘seek’ times when the head has to search the disk for information.  Racetrack memory in a computer is estimated to be 100 times cheaper per bit than flash.
  3. A battery powered by viruses could help run your car or electronic devices. MIT researchers have shown they can genetically engineer viruses to build both the positively and negatively charged ends of a lithium-ion battery. The new virus-produced batteries have the same energy capacity and power performance as state-of-the-art rechargeable batteries being considered to power plug-in hybrid cars, and they could also be used to power a range of personal electronic devices, said Angela Belcher, the MIT materials scientist who led the research team.  The new batteries could be manufactured with a cheap and environmentally benign process: The synthesis takes place at and below room temperature and requires no harmful organic solvents, and the materials that go into the battery are non-toxic.Now that the researchers have demonstrated they can wire virus batteries at the nanoscale, they intend to pursue even better batteries using materials with higher voltage and capacitance, such as manganese phosphate and nickel phosphate, said Belcher. Once that next generation is ready, the technology could go into commercial production, she said.
  4. An important piece in clean coal technology – carbon sequestration – may have a sparkling future. New research shows that for thousands of years carbon dioxide has been stored safely and naturally in underground water in gas fields saturated with the greenhouse gas. The findings – published in Nature – bring carbon capture and storage a step closer. Politicians are committed to cutting levels of atmospheric carbon dioxide to slow climate change. Carbon capture and storage is one approach to cut levels of the gas until cleaner energy sources are developed.  Naturally-occurring carbon dioxide can be trapped in two ways. The gas can dissolve in underground water – like bottled sparkling water. It can also react with minerals in rock to form new carbonate minerals, essentially locking away the carbon dioxide underground.  Real studies to support either of these predictions had, until now, been missing.  This study showed that carbon dioxide has been stored naturally and safely in underground water in natural gas fields.  This new approach will be essential for monitoring and tracing where carbon dioxide captured from coal-fired power stations goes when we inject it underground – this is critical for future safety verification.
  5. World’s first nanofluidic device with complex 3-D surfaces. Researchers at the Commerce Department’s National Institute of Standards and Technology (NIST) and Cornell University have capitalized on a process for manufacturing integrated circuits at the nanometer (billionth of a meter) level and used it to develop a method for engineering the first-ever nanoscale fluidic (nanofluidic) device with complex three-dimensional surfaces. As described in a paper published in the journal Nanotechnology, the Lilliputian chamber is a prototype for future tools with custom-designed surfaces to manipulate and measure different types of nanoparticles in solution.  Among the potential applications for this technology: the processing of nanomaterials for manufacturing; the separation and measuring of complex nanoparticle mixtures for drug delivery, gene therapy and nanoparticle toxicology; and the isolation and confinement of individual DNA strands for scientific study as they are forced to unwind and elongate (DNA typically coils into a ball-like shape in solution) within the shallowest passages of the device.

Filed under: Health, Science, Technology, ,

Mr. Softy’s becoming a retailer?

apple_store_smallMicrosoft is pursuing its ambitions in retail by planning store operations of its own.  It has hired David Porter to spearhead its efforts.  Mr. Porter was most recently the head of worldwide distribution for DreamWorks Animation SKG.  He also brings 25 years of experience from Wal-Mart.

Critics are already shoveling dirt over the perceived grave of said effort.  I’m withholding  judgment till I see it played out.  Their reasoning behind such a push is really what piques my interest.  As you may recall, Microsoft had once ventured down this path in 1999 through a large store in the Metreon center in San Francisco.  The doors were quietly shuttered within two years.

Fast forward ten years and we have another effort by Microsoft to operate its own stores.  Why does a company that has 90+% of the worldwide PC market need to enter into the brick-and-mortar retailing business?  How much more can it gain through sales at these stores?

I think discussions around marketshare miss the point.  The real issue is consumer mindshare.  Although Microsoft has tried to expand into areas such as search, gaming, music, mapping, etc., its cash cow still remains the operating system and Office suite of applications.  The latest incarnation of its operating system, Vista, has not received the acceptance that Microsoft had hoped.  When it comes to innovation, companies like Apple and Google are capturing consumers’ attention.  Microsoft, although ubiquitous, finds itself falling off consumers’ radar.

Here are a couple of charts to illustrate my point:

The first chart was produced using Google Trends.  aaplvmsft_search_volumeYou can use their tool to compare the frequency of occurrence of your term/s relative to the total number of Google searches.  The results are expressed as “Sales Volume Index” which is the volume of your search term relative to total search volume.  Although these results would not pass the test of scientific rigor, they do provide interesting insight.

I compared the terms “Apple” and “Microsoft.”  The green line represents Microsoft while the orange line represents Apple.  The chart shows results of  searches conducted worldwide over the past five years.  Of interest here is the steady loss of mindshare, expressed through search, that Microsoft has suffered relative to Apple.

Now take a look at the second chart which compares the relative market cap of the two companies.  aaplvmsft_mkt_capThe numbers are normalized to Apple’s market cap in January 2004 of $8.4 billion.  Microsoft’s market cap in 2004 was 36x that of Apple’s.  You’ll notice that the general trend since then has been similar to that of the Sales Volume Index.  While Apple’s market cap has increased 1000% in the past five years, Microsoft’s relative market cap has seen a 50% decline.  One of the reasons for the decline is the steady erosion of Microsoft’s traction with the consumer.

With the next version of its operating system, Windows 7, Microsoft wants, and needs, to prove to the consumer that they can have a better experience with its products than they do with Apple or Google.  Maybe getting them into a  vertically integrated store is the solution.  Microsoft would control all aspects of the store and the experience.

Whether successful or not, Microsoft feels that it needs to try because consumer confidence, once lost, is enormously difficult to regain.  Just ask the Big Three auto makers.

Filed under: Business, Technology, , ,